Arquette reflected on becoming a mother at 20 and the many roles she’s held since. Her children are grown: son Enzo, 37, with ex Paul Rossi, and daughter Harlow, 23, with ex-husband Thomas Jane. She and Jane divorced in 2010, and she was previously married to Nicolas Cage from 1995 to 2001.
Speaking with PEOPLE in November 2025, Arquette compared this phase to a renewed season of life — a time for new trips, reconnecting with people she misses, and making choices just for herself. Her gala appearance reinforced that she’s relishing this next chapter on her own terms.